The Ultimate list of CBD Studies

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We know it can be hard to determine which CBD health claims are completely false and which claims are backed by promising research studies. Below you can find a list of our favorite CBD studies sorted by disease/ailment.

Epilepsy

The Interplay between the Endocannabinoid System, Epilepsy and Cannabinoids.

  • The following research article covers Epilepsy and Neuroinflammation, The Role of the ECS system in Neuroinflammation and Epilepsy, Cannabinoids as an Emerging Treatment for Drug-Resistant Epilepsy, and Biomarkers for Determining Neuroinflammation and Monitoring Cannabinoid effects. “Cannabinoids (particularly CBD) show promise as a potent antiseizure treatment, but the promiscuous binding affinity of the cannabinoids for numerous receptors makes the task of identifying their beneficial and detrimental mechanisms of action challenging. ” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6929011/

Use of Cannabidiol in the Treatment of Epilepsy: Efficacy and Security in Clinical Trials

  • At least 14 clinical trials have been completed on cannabidiol and epilepsy. In each study CBD was used in conjunction with anti-epileptic drugs. Some of the most promising results of the studies include: Reduction of seizures of 63.6% after 12 weeks of treatment, the median frequency of seizures decreased from 12,4 to 5.9, and overall improvement of illness. This article also includes a list of some of the ongoing trials attempting to evaluate the efficacy of CBD as an anti-epileptic. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6514832/

Anxiety

Cannabidiol in Anxiety and Sleep: A Large Case Series

  • A study conducted on 103 adult patients aimed to determine whether CBD helps improve sleep and/or anxiety in a clinical population. 79.2% of patients saw a decrease in anxiety in the first month that remained decreased during the study duration. Sleep scores decreased in 66.7% of patients in the first month but fluctuated over time. CBD was tolerated well by all but 3 patients. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6326553/

Cannabidiol as a Potential Treatment for Anxiety Disorders

  • ” Preclinical evidence conclusively demonstrates CBD’s efficacy in reducing anxiety behaviors relevant to multiple disorders, including PTSD, GAD, PD, OCD, and SAD, with a notable lack of anxiogenic effects.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4604171/

Cannabidiol regulation of emotion and emotional memory processing: relevance for treating anxiety‐related and substance abuse disorders

  • This is an excellent article on anxiety for humans and animals. It covers the pharmacological mechanisms and brain sites involved in the anxiety effects of CBD. It also covers emotional learning and memory processing as well as the effects CBD has on fear memory processing. “Converging lines of evidence have established that acute CBD treatment is an anxiolytic in both animals and humas. A growing number of preclinical studies also indicate that this drug reduces fear memory expression when given acutely.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595771/

Evidences for the Anti-panic Actions of Cannabidiol

  • This study aims to discuss the anti-panic effects of CBD in both human and animal studies. ” Taken together, the results presented in this chapter, which were derived from both laboratory animal and human studies, support the notion that CBD exhibits anti-panic properties. Despite the described panic response reported as a result of cannabis use, it is important to note that CBD does not present psychoactive effects; it is safe and well-tolerated via the oral route (up to 1,500 mg/day) [19]. Moreover, because this compound does not induce dependence, tolerance and abstinence symptoms, it can be, in the future, a good alternative as a substitute for high potency benzodiazepines and antidepressant drugs in PD patients who are resistant to the current treatments. ” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5412699/

Osteoarthritis

Attenuation of early phase inflammation by cannabidiol prevents pain and nerve damage in rat osteoarthritis

  • The work completed in this study was supported by an operating grant through The Arthritis Society. ” This study showed for the first time that local CBD administration inhibited pain and peripheral sensitization in established Osteoarthritis. CBD may be a safe therapeutic to treat OA pain locally as well as block the acute inflammatory flares that drive disease progression and joint neuropathy.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5690292/

Antidepressant

Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors